1133 Analysis of the trabecular meshwork in eyes with pseudoexfoliation glaucoma
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چکیده
منابع مشابه
1133 Analysis of the trabecular meshwork in eyes with pseudoexfoliation glaucoma
Purpose: To determine whether mobile trabecular meshwork cell$ can contract collagen matrices in vitro Methods: Bovine and human meshwork cells were cultured and seeded into or onto type I collagen matrices in sterile conditions. The tloating matrices were measured on a daily basis to determine redtlction in diameter over time. Results: The meshwork cells contracted the collagen gells in a time...
متن کاملAqueous Humor Levels of Soluble Fas and Fas-ligand in Patients with Primary Open Angle and Pseudoex-foliation Glaucoma
Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis. Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in ...
متن کاملTrabecular meshwork in pseudoexfoliation syndrome with and without open-angle glaucoma. A morphometric, ultrastructural study.
PURPOSE To test the hypothesis that glaucoma in eyes with pseudoexfoliation (PEX) syndrome results from blockage of the outflow channels by PEX material, melanin granules from the iris pigment epithelium, or both, and to determine the origin of intratrabecular PEX material. METHODS Trabecular meshwork tissue was obtained from five surgically enucleated eyes with PEX glaucoma, ten autopsy eyes...
متن کاملDetection of differentially expressed glycogenes in trabecular meshwork of eyes with primary open-angle glaucoma.
PURPOSE To identify differentially expressed glycogenes in trabecular meshwork (TM) of eyes with primary open-angle glaucoma (POAG). METHODS Total RNA was isolated from TM of cadaveric eyes derived from donors with diagnosed glaucomas of different etiologies and from normal control subjects. RNA was amplified and hybridized to the GLYCOv2 oligonucleotide microarray that contains probes for ca...
متن کاملMitochondrial damage in the trabecular meshwork of patients with glaucoma.
OBJECTIVES To analyze the frequency of mitochondrial DNA (mtDNA) damage in patients with primary open-angle glaucoma. Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species. METHODS Mitochondrial damage was evaluated analyzing a ...
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ژورنال
عنوان ژورنال: Vision Research
سال: 1995
ISSN: 0042-6989
DOI: 10.1016/0042-6989(95)90030-6